Our U.S. COVID-19 Response team embedded staff members with the Wake County, North Carolina Department of Health and Human Services (WCHHS) to protect and improve community health during the pandemic. Beginning in February 2021, WCHHS began implementing a vaccine equity strategy to reach underserved communities. One of the prioritized census tracts increased vaccinations by 29.7% relative to other non-prioritized tracts in the county. Canvassing efforts and geo-targeted information campaigns were instrumental in building trust between community members and vaccine providers, which led to more people getting vaccinated through word-of-mouth encouragement.