Trans fat elimination

Artificial trans fat can be eliminated and replaced with healthier alternatives.

Trans fat is a harmful compound that increases the risk of heart attack and death. 

It is estimated to cause more than half a million deaths every year, globally.  

The number of countries taking action is accelerating rapidly

Bar chart demonstrating countries implementing best-practice trans fat bans by year through march 2025, starting with Denmark in 2003 and escalating rapidly in 2018 with the launch of RTSL + WHO's REPLACE initiative.

Our goal

Eliminate artificial trans fat from the global food supply.

How we work

We partnered with the World Health Organization (WHO) to develop and support REPLACE, an initiative to eliminate artificial trans fat from the global food supply by providing governments the tools to regulate trans fat and manufacturers the recipe to do so. The REPLACE action package is a six-module, step-by step guide for governments to eliminate trans fat from their food supply.

We also work with national governments to pass and implement best practice policies to eliminate exposure to trans fat and increase the availability of healthier alternatives. In collaboration with our partner, the Global Health Advocacy Incubator, we also support local civil society organizations to make the case for trans fat elimination to national governments and the public.

We support public awareness campaigns to build support for removing trans fat from the global food supply. We also support research on trans fat levels in food and are working with WHO to build lab capacity across multiple regions. 

Our work in action

  • Since the REPLACE initiative was announced in 2018, an additional 50 countries (3.4 billion people) have gained protection through policies eliminating trans fat.
  • At the start of 2025, 3.9 billion people—just under half the global population—lived in countries with best practice trans fat elimination policies in place.
  • We’ve created resources to support countries to eliminate trans fat, including a Trans Fat Regulatory Drafting Tool, and have called on major global food producers to eliminate trans fat from their products worldwide.
  • Countdown to 2023: WHO report on global trans-fat elimination  offers detailed information on the status of trans fat elimination efforts around the world.

Where we work:  Trans fat elimination

Publications and Resources

NYC trans fat ban

Eliminating trans fat: Only your heart will know the difference

Dr. Tom Frieden explains how New York City successfully banned trans fat and became a model for eliminating this toxic food additive. 
Cover image for GHAI's position paper on Mandatory Sodium Reduction Targets for Processed Foods with support from Resolve to Save Lives

Position paper: Mandatory sodium reduction targets for processed foods

Clear, evidence-based recommendations to guide policymakers and advocates in shaping and advancing mandatory sodium reduction targets. 
Global Health Advocacy Incubator
nutrientprofilemodels

Using nutrient profile models to underpin key nutrition interventions

Use nutrient profile models to rank food based on nutritional composition for healthy and comprehensive nutrition policies.
Resolve to Save Lives
9 Million lives saved and counting

9 million lives saved and counting

Heart health partnerships between 2018 and 2023 will result in 9 million fewer deaths worldwide. This report details how.
Resolve to Save Lives

Latest news on trans fat elimination

Putting Nigeria’s trans fat elimination policy into action

October 20, 2025

In 2023, Nigeria made history as the second African country to adopt a best-practice policy to eliminate industrially produced trans fats from the national food supply. Building on this milestone,…

Global Week for Action: Key actions to successfully eliminate toxic trans fat

October 17, 2025

Eliminating trans frat from the global food supply is a proven, cost-effective way to save thousands of lives each year from heart attack and stroke. So how do we do…

what it takes to eliminate trans fat

New video from Dr. Frieden: What it takes to eliminate trans fat

July 29, 2025
In a new video, Dr. Frieden, President and CEO of Resolve to Save Lives, talks about the dangers of artificial trans fat and his efforts to eliminate trans fat in…