She was the World Health Organisation Director of Public Health Innovation and Intellectual Property. Prior to that, she served as WHO Director, Department of Technical Cooperation for Essential Drugs and Traditional Medicines. She was the Registrar of the Medicines Control Council for six years. She has served on various advisory bodies both nationally and internationally and was Chair of the WHO Executive Board. She served as a member of the UN High-Level Panel on Access to Health Technologies, Chairperson of the Independent Oversight and Advisory Committee for the WHO Health Emergencies Programme. She was a member of the Lancet Global Health Commission on High Quality Health Systems. She was the Co-Chair of WHO Digital Health Advisory Group. She was appointed as a member of the Independent Panel for Pandemic Preparedness and Response.
Precious Matsoso is currently the Co-chair of the Intergovernmental Negotiating Body to Draft and Negotiate a WHO Convention, agreement or other international instrument on pandemic prevention, preparedness, and response (INB). She is the Director of the Health Regulatory Science Platform, a division of the Wits Health Consortium and an Honorary Lecturer in the Department of Pharmacy and Pharmacology, University of the Witwatersrand.