In a new article for the Journal of the American College of Cardiology, experts from Resolve to Save Lives, World Health Organization, Global Health Advocacy Incubator, and NCD Alliance describe global progress and efforts to eliminate trans fat from the food supply. Since the formation of the global partnership and launch of REPLACE, 43 countries have taken action against the harms of trans fat. The paper outlines the components that have contributed to the success of the initiative and highlights the remaining challenges.