The Smithsonian exhibition, Outbreak: Epidemics in a Connected World, shows that the world cannot afford to wait for the next epidemic—we must act on the information that we have now to end preventable outbreaks. Writing for the Lancet, Resolve to Save Lives reflects on the impact of epidemics over the past century, from Nipah virus to HIV and Ebola. It underscores the importance of coordinated global efforts in epidemic preparedness, emphasizing the lessons learned from previous outbreaks. Despite progress, significant gaps remain in disease surveillance, community engagement, and health care capacity. A safer future for all will require ongoing education, collaboration, and a global commitment to addressing vulnerabilities.