In a commentary for BMJ Global Health, Resolve to Save Lives takes lessons from the COVID-19 pandemic and proposes an updated understanding of pandemic preparedness. Moving forward, we must secure increased and sustained funding from governments, while enhancing technical capacities and operational excellence in public health systems worldwide. Strengthening our global health architecture demands a commitment from countries, effective governance, and responsible use of resources. We need strong, accountable global leadership and robust technical support, backed by substantial new funding and efficient financial mechanisms. Ultimately, success hinges on fostering collaboration, recognizing our interdependence, and establishing mutual accountability in our efforts.