Strict adherence to infection prevention and control measures, and timely implementation of nonpharmaceutical interventions, can help prevent and control COVID-19. Writing in Emerging Infectious Diseases, experts at Resolve to Save Lives examine the role of superspreading events (SSEs) in the rapid spread of SARS-CoV-2, highlighting their potential to accelerate outbreaks and prolong transmission. We emphasize the importance of timely public health action, particularly in healthcare settings, to identify and manage these high-risk events. Understanding transmission dynamics and implementing strict infection prevention and control (IPC) protocols are critical to preventing future outbreaks.