Frontline health care workers need full protections in the form of infection prevention and control (IPC) measures, water, sanitation and hygiene (WASH) programs, and expanded training opportunities. Writing in the International Journal of Health Planning and Management, experts at Resolve to Save Lives review health care worker infections and deaths during previous epidemics, illustrating the high human and economic costs of neglecting their safety. The study advocates for comprehensive investment to strengthen healthcare infrastructure and cultural shifts to safeguard those on the frontlines of global health crises.