In the wake of the COVID-19 pandemic, Resolve to Save Lives collaborated with U.S. jurisdictions to create four digital solutions that enhance the efficiency of case investigation and contact tracing to reduce the spread of infectious diseases by enabling more precise outreach, timely interventions, and better confidentiality: Epi Viaduct, Epi Contacts, Epi Locator, and Epi Viewpoint. Epi Viaduct dramatically sped up the transfer of 7.4 million records from over 2.5 hours to under 1 minute. Epi Contacts improved contact elicitation, resulting in 18,700 contacts from 9,440 index cases. Epi Locator facilitated 134,410 searches with a 75% success rate. These technologies, while developed for COVID-19, can also be adapted for managing any communicable disease.