Nigeria’s experience with a self-assessment of pandemic preparedness underscored the need for investment and stakeholder involvement to strengthen health systems. Writing for Health Security, our colleagues at Nigeria Centres for Disease Control and Prevention reviewed Nigeria’s experience conducting a midterm self-assessment of its pandemic preparedness using a modified World Health Organization (WHO) Joint External Evaluation (JEE) framework and the WHO benchmarks tool. The assessment identified improvements in 11 out of 19 technical areas between 2017 and 2019 and culminated in the development of a 12-month operational plan aimed at enhancing Nigeria’s pandemic readiness.