Artificial trans fat can be eliminated and replaced with healthier alternatives.
Trans fat is a harmful compound that increases the risk of heart attack and death.
It is estimated to cause more than half a million deaths every year, globally.
The number of countries taking action is accelerating rapidly
Our Goal
To eliminate artificial trans fat from the global food supply, which would prevent 250,000 heart disease deaths each year among adults younger than 70.
How we work
We partnered with the World Health Organization (WHO) to develop and support REPLACE, an initiative to eliminate artificial trans fat from the global food supply by providing governments the tools to regulate trans fat and manufacturers the recipe to do so. The REPLACE action package is a six-module, step-by step guide for governments to eliminate trans fat from their food supply.
We also work with national governments to pass and implement best practice policies to eliminate exposure to trans fat and increase the availability of healthier alternatives. In collaboration with our partner, the Global Health Advocacy Incubator, we also support local civil society organizations to make the case for trans fat elimination to national governments and the public.
We support public awareness campaigns to build support for removing trans fat from the global food supply. We also support research on trans fat levels in food and are working with WHO to build lab capacity across multiple regions.

Our Work in Action

- Since the REPLACE initiative was announced in 2018, an additional 35 countries (2.6 billion people) have gained protection through policies eliminating trans fat.
- At the end of 2022, 3.1 billion people—just over one third of the global population—lived in countries with best practice trans fat elimination policies in place.
- We’ve created resources to support countries to eliminate trans fat, including a Trans Fat Regulatory Drafting Tool, and have called on major global food producers to eliminate trans fat from their products worldwide.
- Countdown to 2023: WHO report on global trans-fat elimination 2022 offers detailed information on the status of trans fat elimination efforts around the world.
Where We Work: Trans Fat Elimination
Anguilla
Resolve to Save Lives partners with the Pan American Health Organization to support the continued scale up of HEARTS, the World Health Organization technical package for improving cardiovascular health.
Projects
Antigua and Barbuda
Resolve to Save Lives partners with the Pan American Health Organization to support the continued scale up of HEARTS, the World Health Organization technical package for improving cardiovascular health.
Projects
Argentina
Resolve to Save Lives supports the implementation of REPLACE, the World Health Organization technical package for eliminating trans fat from the global food supply.
Resolve to Save Lives partners with the Pan American Health Organization to support the continued scale up of HEARTS, the World Health Organization technical package for improving cardiovascular health.
Projects
Armenia
Resolve to Save Lives partners with the World Health Organization (WHO) to support the implementation of REPLACE, the WHO technical package for eliminating trans fat from the global food supply.
With the support of a grant from the LINKS Community, the World Health Organization’s European Office for the Prevention and Control of Noncommunicable Diseases is working to reduce salt intake in the Caucasus region (Georgia, Armenia, and Azerbaijan).
Projects
Aruba
Resolve to Save Lives partners with the Pan American Health Organization to support the continued scale up of HEARTS, the World Health Organization technical package for improving cardiovascular health.
Projects
Azerbaijan
With the support of a grant from the LINKS Community, the World Health Organization’s European Office for the Prevention and Control of Noncommunicable Diseases is working to reduce salt intake in the Caucasus region (Georgia, Armenia, and Azerbaijan).
Bahamas
Resolve to Save Lives partners with the Pan American Health Organization to support the continued scale up of HEARTS, the World Health Organization technical package for improving cardiovascular health.
Projects
Bangladesh
Projects
Barbados
Resolve to Save Lives partners with the Pan American Health Organization to support the continued scale up of HEARTS, the World Health Organization technical package for improving cardiovascular health.
Projects
Belize
Resolve to Save Lives partners with the Pan American Health Organization to support the continued scale up of HEARTS, the World Health Organization technical package for improving cardiovascular health.
Projects
Bermuda
Resolve to Save Lives partners with the Pan American Health Organization to support the continued scale up of HEARTS, the World Health Organization technical package for improving cardiovascular health.
Projects
Bhutan
Projects
Bolivia
Resolve to Save Lives partners with Pan American Health Organization to support sodium reduction initiatives.
Projects
Brazil
Prevent Epidemics provides technical assistance directly or through partners, mobilizes resources to support preparedness and drives political support to address epidemic preparedness gaps. Programmatic interventions include laboratory strengthening, disease surveillance, legal support, rapid response funding and program management/governance.
In Brazil, Prevent Epidemics is implementing the 7-1-7 approach to rapid performance improvement for early disease detection and response.
Success Story
Addressing COVID-19 in Brazil with Consistent CommunicationProjects
British Virgin Islands
Resolve to Save Lives supports hypertension control initiatives and t the continued scale up of HEARTS, the World Health Organization technical package for improving cardiovascular health.
Projects
Burkina Faso
Prevent Epidemics provides technical assistance directly or through partners, mobilizes resources to support preparedness and drives political support to address epidemic preparedness gaps. Programmatic interventions include laboratory strengthening, disease surveillance, legal support, rapid response funding and program management/governance.
Success Story
Expanding Quality-Assured COVID-19 Testing Capacity Across AfricaSuccess Story
Fighting COVID-19 on the Airwaves and in the Markets: Coordinated Campaigns for Protective BehaviorsProjects
Burundi
Projects
Cabo Verde
Resolve to Save Lives supported the World Health Organization national strategic COVID-19 vaccine deployment plan.
Cameroon
Prevent Epidemics provides technical assistance directly or through partners, mobilizes resources to support preparedness and drives political support to address epidemic preparedness gaps. Programmatic interventions include laboratory strengthening, disease surveillance, legal support, rapid response funding and program management/governance.
Success Story
Expanding Quality-Assured COVID-19 Testing Capacity Across AfricaProjects
Canada
Projects
Cayman Islands
Resolve to Save Lives partners with the Pan American Health Organization to support the continued scale up of HEARTS, the World Health Organization technical package for improving cardiovascular health.
Projects
Chile
Resolve to Save Lives partners with the Pan American Health Organization to support the continued scale up of HEARTS, the World Health Organization technical package for improving cardiovascular health.
Success Story
During a Pandemic, Addressing Another Leading Killer: Hypertension
Projects
China
Projects
Colombia
Resolve to Save Lives partners with the Pan American Health Organization to support the continued scale up of HEARTS, the World Health Organization (WHO) technical package for improving cardiovascular health, as well as REPLACE, the WHO technical package for eliminating trans fat from the global food supply.
Resolve supports COVID-19 risk communication efforts and funds civil registration and vital statistics work in-country.
Projects
Costa Rica
INCIENSA, a LINKS grantee, is using an evidence-based approach to salt intake reduction in Costa Rica.
Centro para la Defensa del Consumidor, a LINKS grantee, is using an evidence-based approach to salt intake reduction in Costa Rica
Resolve to Save Lives partners with the Pan American Health Organization to support the continued scale up of HEARTS, the World Health Organization technical package for improving cardiovascular health.
Projects
Cuba
Resolve to Save Lives partners with the Pan American Health Organization to support continued scale up of HEARTS, the World Health Organization technical package for improving cardiovascular health.
Projects
Curaçao
Resolve to Save Lives partners with the Pan American Health Organization to support the continued scale up of HEARTS, the World Health Organization technical package for improving cardiovascular health.
Projects
Democratic Republic of the Congo
Prevent Epidemics provides technical assistance directly or through partners, mobilizes resources to support preparedness and drives political support to address epidemic preparedness gaps. Programmatic interventions include laboratory strengthening, disease surveillance, legal support, rapid response funding and program management/governance.
In DRC, Prevent Epidemics partners with the Director General of Disease Control to embed an A-Team, a multidisciplinary team working across government offices to help plan and implement a range of activities required to accelerate epidemic preparedness.
Success Story
Democratic Republic of Congo: Addressing Complex Health Challenges through Preparation and TrainingProjects
Dominica
Resolve to Save Lives partners with the Pan American Health Organization to support the continued scale up of HEARTS, the World Health Organization technical package for improving cardiovascular health.
Resolve to Save Lives partners with the Pan American Health Organization to support the continued scale up of HEARTS, the World Health Organization technical package for improving cardiovascular health.
Projects
Dominican Republic
In the Dominican Republic, Resolve to Save Lives partners with the Pan American Health Organization to support continued scale up of HEARTS, the World Health Organization technical package for improving cardiovascular health.
Projects
Ecuador
Resolve to Save Lives partners with the Pan American Health Organization (PAHO) to support the continued scale up of HEARTS, the World Health Organization (WHO) technical package for improving cardiovascular health, as well as REPLACE, the WHO technical package for eliminating trans fat from the global food supply.
A grant from the LINKS Community supports PAHO in working to improve control of high blood pressure in Ecuador by training health staff and developing monitoring and evaluation tools.
Projects
El Salvador
Resolve to Save Lives partners with the Pan American Health Organization to support the continued scale up of HEARTS, the World Health Organization technical package for improving cardiovascular health.
Resolve to Save Lives partners with the Pan American Health Organization to support the continued scale up of HEARTS, the World Health Organization technical package for improving cardiovascular health.
Projects
Ethiopia
Prevent Epidemics provides technical assistance directly or through partners, mobilizes resources to support preparedness and drives political support to address epidemic preparedness gaps. Programmatic interventions include laboratory strengthening, disease surveillance, legal support, rapid response funding and program management/governance.
Prevent Epidemics partners with the Ethiopian Public Health Institute to embed an A-Team, a multidisciplinary team working across government offices to help plan and implement a range of activities required to accelerate epidemic preparedness.
Prevent Epidemics partners with the Ethiopian Public Health Institute to improve health care worker safety, including via strengthening infection prevention and control (IPC) measures, which keep health care workers and patients safe from avoidable infections.
Prevent Epidemics partners with the Ethiopian Public Health to implement the 7-1-7 approach to rapid performance improvement for early disease detection and response.
Success Story
Expanding Quality-Assured COVID-19 Testing Capacity Across AfricaProjects
French Guiana
Resolve to Save Lives partners with the Pan American Health Organization to support the continued scale up of HEARTS, the World Health Organization technical package for improving cardiovascular health.
Projects
Gabon
Prevent Epidemics provides technical assistance directly or through partners, mobilizes resources to support preparedness and drives political support to address epidemic preparedness gaps. Programmatic interventions include laboratory strengthening, disease surveillance, legal support, rapid response funding and program management/governance.
Success Story
Expanding Quality-Assured COVID-19 Testing Capacity Across AfricaProjects
Georgia
With the support of a grant from the LINKS Community, the World Health Organization’s European Office for the Prevention and Control of Noncommunicable Diseases is working to reduce salt intake in the Caucasus region (Georgia, Armenia, and Azerbaijan).
Projects
Ghana
Prevent Epidemics provides technical assistance directly or through partners, mobilizes resources to support preparedness and drives political support to address epidemic preparedness gaps. Programmatic interventions include laboratory strengthening, disease surveillance, legal support, rapid response funding and program management/governance.
Success Story
Expanding Quality-Assured COVID-19 Testing Capacity Across AfricaSuccess Story
Supporting health care workers to promote service continuity during the COVID-19 pandemic in GhanaSuccess Story
Preparation is the Key: Ghana Takes on COVID-19Projects
Grenada
Resolve to Save Lives partners with the Pan American Health Organization to support the continued scale up of HEARTS, the World Health Organization technical package for improving cardiovascular health.
Resolve to Save Lives partners with the Pan American Health Organization to support the continued scale up of HEARTS, the World Health Organization technical package for improving cardiovascular health.
Projects
Guadeloupe
Resolve to Save Lives partners with the Pan American Health Organization to support the continued scale up of HEARTS, the World Health Organization technical package for improving cardiovascular health.
Projects
Guatemala
Resolve to Save Lives partners with the Pan American Health Organization to support the continued scale up of HEARTS, the World Health Organization technical package for improving cardiovascular health.
Projects
Guyana
Resolve to Save Lives partners with the Pan American Health Organization to support the continued scale up of HEARTS, the World Health Organization technical package for improving cardiovascular health.
Projects
Haiti
Success Story
Haiti Serves Critical COVID-19 Information with a Side of EntertainmentProjects
Honduras
Resolve to Save Lives partners with the Pan American Health Organization to support the continued scale up of HEARTS, the World Health Organization technical package for improving cardiovascular health.
Projects
India
Resolve to Save Lives partners with the Indian government, the Indian Council of Medical Research, the Global Health Advocacy Incubator (GHAI) and the George Institute on hypertension control and sodium reduction initiatives, including the Simple app.
Resolve also partners with the World Health Organization (WHO), GHAI and local partners to support the implementation of REPLACE, the WHO technical package for eliminating trans fat from the global food supply.
Success Story
Doorstep medicine delivery for high-risk patients in India during COVID-19 lockdowns
Success Story
During a Pandemic, Addressing Another Leading Killer: Hypertension
Projects
Jamaica
Resolve to Save Lives partners with the Pan American Health Organization to support the continued scale up of HEARTS, the World Health Organization technical package for improving cardiovascular health.
Resolve to Save Lives partners with the Pan American Health Organization to support the continued scale up of HEARTS, the World Health Organization technical package for improving cardiovascular health.
Projects
Kenya
Success Story
Expanding Quality-Assured COVID-19 Testing Capacity Across AfricaSuccess Story
Real-time data to inform decision-making about maintaining health services in Kenya during the COVID-19 pandemicProjects
Kuwait
Kyrgyzstan
Resolve to Save Lives partners with the World Health Organization (WHO) to support the implementation of REPLACE, the WHO technical package for eliminating trans fat from the global food supply.
Projects
Lebanon
Liberia
Prevent Epidemics provides technical assistance directly or through partners, mobilizes resources to support preparedness and drives political support to address epidemic preparedness gaps. Programmatic interventions include laboratory strengthening, disease surveillance, legal support, rapid response funding and program management/governance.
Prevent Epidemics partners with the National Public Health Institute of Liberia to embed an A-Team, a multidisciplinary team working across government offices to help plan and implement a range of activities required to accelerate epidemic preparedness.
In Liberia, Prevent Epidemics partners with Last Mile Health to improve health care worker safety, including via strengthening infection prevention and control (IPC) measures, which keep health care workers and patients safe from avoidable infections.
Prevent Epidemics partners with the National Public Health Institute of Liberia to implement the 7-1-7 approach to rapid performance improvement for early disease detection and response.
Success Story
Training the Trainers: Securing the Foundation of an Effective COVID-19 Response in LiberiaProjects
Malaysia
With support from a grant from the LINKS Community, the Ministry of Health Malaysia and partners are working to accelerate mandatory sodium labelling, and to inform and engage the food industry in reformulation efforts.
Projects
Maldives
Resolve to Save Lives partners with the World Health Organization (WHO) to support the implementation of REPLACE, the WHO technical package for eliminating trans fat from the global food supply.
Projects
Martinique
Resolve to Save Lives partners with the Pan American Health Organization to support the continued scale up of HEARTS, the World Health Organization technical package for improving cardiovascular health.
Projects
Mauritania
Success Story
Mauritania: Getting Eyes on the Virus
Mexico
Resolve to Save Lives partners with the Pan American Health Organization to support the continued scale up of HEARTS, the World Health Organization technical package for improving cardiovascular health.
Resolve also supports the COVID-19 response and ongoing epidemic preparedness through risk communication efforts.
Projects
Montenegro
Resolve to Save Lives supports sodium reduction initiatives and the implementation of REPLACE, the WHO technical package for eliminating trans fat from the global food supply.
Projects
Montserrat
Resolve to Save Lives partners with the Pan American Health Organization to support the continued scale up of HEARTS, the World Health Organization technical package for improving cardiovascular health.
Projects
Nepal
Projects
Netherlands Antilles
Resolve to Save Lives partners with the Pan American Health Organization to support the continued scale up of HEARTS, the World Health Organization technical package for improving cardiovascular health.
Projects
Nicaragua
Resolve to Save Lives partners with the Pan American Health Organization to support the continued scale up of HEARTS, the World Health Organization technical package for improving cardiovascular health.
Projects
Nigeria
Prevent Epidemics provides technical assistance directly or through partners, mobilizes resources to support preparedness and drives political support to address epidemic preparedness gaps. Programmatic interventions include laboratory strengthening, disease surveillance, legal support, rapid response funding and program management/governance.
In Nigeria, Prevent Epidemics partnered with the Nigeria Centre for Disease Control to embed an A-team, a multidisciplinary team working across government offices to help plan and implement a range of activities required to accelerate epidemic preparedness. The team has since become part of RTSL in partnership with NCDC.
In Nigeria, Prevent Epidemics partners with the African Field Epidemiology Network to improve health care worker safety, including via strengthening infection prevention and control (IPC) measures, which keep health care workers and patients safe from avoidable infections.
In Nigeria, Prevent Epidemics partners with the Nigeria Centre for Disease Control to implement the 7-1-7 approach to rapid performance improvement for early disease detection and response.
Success Story
Improving the Ability to Test for Yellow Fever: A Low-Cost, Country-Led Intervention in NigeriaSuccess Story
How Real-Time Adaptations To Medical Supply Chains Improved Nigeria’s COVID-19 ResponseSuccess Story
Beyond COVID-19: Nigeria’s Efforts to Balance the Pandemic ResponseProjects
Panama
In Panama, Resolve to Save Lives partners with the Pan American Health Organization to support continued scale up of HEARTS, the World Health Organization technical package for improving cardiovascular health.
Resolve to Save Lives partners with the Pan American Health Organization to support the continued scale up of HEARTS, the World Health Organization technical package for improving cardiovascular health.
Success Story
During a Pandemic, Addressing Another Leading Killer: Hypertension
Projects
Paraguay
Resolve to Save Lives partners with the Pan American Health Organization to support the continued scale up of HEARTS, the World Health Organization technical package for improving cardiovascular health.
Projects
Peru
Resolve to Save Lives partners with the Pan American Health Organization to support the continued scale up of HEARTS, the World Health Organization technical package for improving cardiovascular health.
Resolve also funds civil registration and vital statistics work in-country.
Projects
Philippines
Resolve to Save Lives partners with the Filipino government and the World Health Organization (WHO) to support hypertension control and sodium reduction initiatives.
Resolve also partners with WHO and the Global Health Advocacy Incubator to support the implementation of REPLACE, the WHO technical package for eliminating trans fat from the global food supply.
LINKS grantee, Interactive Research and Development, is establishing a model for effective hypertension treatment in the private sector by piloting a program in Marikina City, Manila.
Projects
Puerto Rico
Resolve to Save Lives partners with the Pan American Health Organization to support the continued scale up of HEARTS, the World Health Organization technical package for improving cardiovascular health.
Projects
Rwanda
Projects
Saint Kitts and Nevis
Resolve to Save Lives partners with the Pan American Health Organization to support the continued scale up of HEARTS, the World Health Organization technical package for improving cardiovascular health.
Projects
Saint Lucia
Resolve to Save Lives partners with the Pan American Health Organization to support the continued scale up of HEARTS, the World Health Organization technical package for improving cardiovascular health.
Projects
Saint Martin (French)
Projects
Saint Vincent and the Grenadines
Resolve to Save Lives partners with the Pan American Health Organization to support the continued scale up of HEARTS, the World Health Organization technical package for improving cardiovascular health.
Projects
São Tomé and Príncipe
Prevent Epidemics provides technical assistance directly or through partners, mobilizes resources to support preparedness and drives political support to address epidemic preparedness gaps. Programmatic interventions include laboratory strengthening, disease surveillance, legal support, rapid response funding and program management/governance.
Success Story
Expanding Quality-Assured COVID-19 Testing Capacity Across AfricaProjects
Senegal
Prevent Epidemics provides technical assistance directly or through partners, mobilizes resources to support preparedness and drives political support to address epidemic preparedness gaps. Programmatic interventions include laboratory strengthening, disease surveillance, legal support, rapid response funding and program management/governance.
Success Story
Senegal makes the case for investing in epidemic preparedness and responseProjects
Sierra Leone
Prevent Epidemics provides technical assistance directly or through partners, mobilizes resources to support preparedness and drives political support to address epidemic preparedness gaps. Programmatic interventions include laboratory strengthening, disease surveillance, legal support, rapid response funding and program management/governance.
In Sierra Leone, Prevent Epidemics partners with ICAP to improve health care worker safety, including via strengthening infection prevention and control (IPC) measures, which keep health care workers and patients safe from avoidable infections.
Success Story
Empowering Medical Staff to Prevent and Control COVID-19 in Sierra LeoneProjects
Sri Lanka
Projects
Suriname
Resolve to Save Lives partners with the Pan American Health Organization to support the continued scale up of HEARTS, the World Health Organization technical package for improving cardiovascular health.
Projects
Tajikistan
Tanzania
Thailand
Resolve to Save Lives partners with the Thailand Ministry of Public Health and the World Health Organization (WHO) to support hypertension control and sodium reduction initiatives.
Resolve partners with the CDC to support the implementation of REPLACE, the WHO technical package for eliminating trans fat from the global food supply.
Success Story
During a Pandemic, Addressing Another Leading Killer: Hypertension
Projects
The Gambia
Prevent Epidemics provides technical assistance directly or through partners, mobilizes resources to support preparedness and drives political support to address epidemic preparedness gaps. Programmatic interventions include laboratory strengthening, disease surveillance, legal support, rapid response funding and program management/governance.
Success Story
The Gambia: Modernizing Laws to Enable Public Health ActionSuccess Story
Expanding Quality-Assured COVID-19 Testing Capacity Across AfricaProjects
Togo
Prevent Epidemics provides technical assistance directly or through partners, mobilizes resources to support preparedness and drives political support to address epidemic preparedness gaps. Programmatic interventions include laboratory strengthening, disease surveillance, legal support, rapid response funding and program management/governance.
Success Story
Leveraging legal advancements to slow COVID-19 in TogoSuccess Story
Fighting COVID-19 on the Airwaves and in the Markets: Coordinated Campaigns for Protective BehaviorsProjects
Trinidad and Tobago
Resolve to Save Lives partners with the Pan American Health Organization to support the continued scale up of HEARTS, the World Health Organization technical package for improving cardiovascular health.
Projects
Turkey
Projects
Turks and Caicos Islands
Resolve to Save Lives partners with the Pan American Health Organization to support the continued scale up of HEARTS, the World Health Organization technical package for improving cardiovascular health.
Projects
Uganda
Prevent Epidemics provides technical assistance directly or through partners, mobilizes resources to support preparedness and drives political support to address epidemic preparedness gaps. Programmatic interventions include laboratory strengthening, disease surveillance, legal support, rapid response funding and program management/governance.
In Uganda, Prevent Epidemics partners with the Infectious Diseases Institute to embed an A-Team, a multidisciplinary team working across government offices to help plan and implement a range of activities required to accelerate epidemic preparedness.
In Uganda, Prevent Epidemics partners with the Infectious Diseases Institute to improve health care worker safety, including via strengthening infection prevention and control (IPC) measures, which keep health care workers and patients safe from avoidable infections.
In Uganda, Prevent Epidemics partners with the Infectious Diseases Institute to implement the 7-1-7 approach to rapid performance improvement for early disease detection and response.
Success Story
Expanding Quality-Assured COVID-19 Testing Capacity Across AfricaProjects
United Kingdom
United States of America
Prevent Epidemics provides technical assistance directly or through partners, mobilizes resources to support preparedness and drives political support to address epidemic preparedness gaps. Programmatic interventions include laboratory strengthening, disease surveillance, legal support, rapid response funding and program management/governance.
In the United States, Prevent Epidemics is implementing the 7-1-7 approach to rapid performance improvement for early disease detection and response.
Projects
Uruguay
Resolve to Save Lives partners with the Pan American Health Organization to support the continued scale up of HEARTS, the World Health Organization technical package for improving cardiovascular health.
Projects
Venezuela, Bolivarian Republic of
Resolve to Save Lives partners with the Pan American Health Organization to support the continued scale up of HEARTS, the World Health Organization technical package for improving cardiovascular health.
Projects
Vietnam
Projects
Virgin Islands (British)
Resolve to Save Lives partners with the Pan American Health Organization to support the continued scale up of HEARTS, the World Health Organization technical package for improving cardiovascular health.
Projects
Zambia
Prevent Epidemics provides technical assistance directly or through partners, mobilizes resources to support preparedness and drives political support to address epidemic preparedness gaps. Programmatic interventions include laboratory strengthening, disease surveillance, legal support, rapid response funding and program management/governance.
Projects
Zimbabwe
Prevent Epidemics provides technical assistance directly or through partners, mobilizes resources to support preparedness and drives political support to address epidemic preparedness gaps. Programmatic interventions include laboratory strengthening, disease surveillance, legal support, rapid response funding and program management/governance.
In Zimbabwe, Prevent Epidemics partners with the Biomedical Research and Training Institute to improve health care worker safety, including via strengthening infection prevention and control (IPC) measures, which keep health care workers and patients safe from avoidable infections.